June 15, Tuesday
12:00 – 13:30
Protein Structure Prediction (for non-bioinformatics people) – general overview and my specific contribution to the field
Graduate seminar
Lecturer : Ami levy
Affiliation : CS,BGU
Location : 201/37
Host : Graduate Seminar
In this talk I will begin with a short background for computer scientists on proteins and their structures.
Then I will give a brief overview on some aspects of the challenging field of computational protein structure prediction.
In the second part of the talk I will summarize the main project of my PhD thesis: A novel cooperative energy term for hydrogen bonds.
(In more details: hydrogen bonds are major constituents of protein structures and thus have been subject to many works.
Yet, the common treatment of hydrogen bonds by energy functions is a considerable contributor to the infamous "local minima problem", which has annoyed predictors since the earliest days of this field.
Cooperative terms for hydrogen bonds attempt to ease this problem by shifting the focus from the individual hydrogen bond to patterns of hydrogen bonds.
I will present the main ideas of our novel cooperative hydrogen-bond term that is both effective and computationally efficient).