Protein Expression – Optimizing Outcomes for Maximum Efficiency

Protein Expression

Cambridge Healthtech Institutes’ Eleventh Annual Event

Conference Dates: January 7-9, 2008

Hotel Del Coronado
San Diego, CA

The expression of proteins for characterization, therapeutics, and diagnostics continues to be a challenging and complex task, requiring much time and untold expense. However, new data emerges every day which provides unique insights into methods for producing these proteins. This conference will present the most up-to-date research in protein-expression science and give valuable insights into the new methods and technologies which will make achieving ideal protein expression an obtainable goal.

RAT GENOMICS & MODELS

RAT GENOMICS & MODELS
December 6 – 9, 2007

Cold Spring Harbor Laboratory

Cold Spring Harbor, NY 11724-2213
Phone (516) 367-8346
Fax: (516) 367-8845

You are cordially invited to participate in the fifth meeting on Rat Genomics & Models, which will be held at Cold Spring Harbor Laboratory. The meeting will begin with dinner and the first session on the evening of Thursday, December 6, and will conclude with lunch on Sunday, December 9, 2007. We are looking forward to a broad-based meeting, and abstracts are welcomed on all scientific topics related to rat genetics, genomics and physiology.

6th Workshop: Statistical methods for post-genomic data

6th Workshop: Statistical methods for post-genomic data

January, 31st and February, 1st, 2008

Agrocampus Rennes
65 rue de Saint-Brieuc
CS 84215 – 35042 Rennes cedex

This workshop will focus on statistical methods dedicated to post-genomic data such as transcriptome, proteome… High flow experimental methods aim at identifying the genes functions and their links with a biological process. Statistics and mathematics are useful for providing performant methods for the differential analysis of micro-array data and electrophoresis images and for modelling networks using multiple genomic data. The subjects of interest are the following: mixing models, multiple testing, estimation and variables selection, Bayesian methods, random effects models, kernels methods, classification (supervised or not), change point estimation …

XVth World Congress of Psychiatric Genetics (WCPG)

XVth World Congress of Psychiatric Genetics (WCPG)
Bridging Genes to Behavior in the Era of the Genome

October 7-10, 2007
New York City
The Marriott Marquis, Times Square

This year a 4 day program will be focused on new progress in discovering candidate genes and genetic
mechanisms for all major uniquely human neuropsychiatric disorders and will include topics related to the mapping of the genetic control of normal and abnormal brain plasticity during early development,
childhood, adolescence, adulthood and aging.

Program Announcement (PA) Number: PA-07-413

National Institutes of Health (NIH)

Genetic Epidemiology of Substance Use Disorders

Genetic Epidemiology of Substance Use Disorders (R01)
Genetic Epidemiology of Substance Use Disorders (R03)
Genetic Epidemiology of Substance Use Disorders(R21)

Key Dates.
Release/Posted Date: July 24, 2007
Opening Date: July 25, 2007 (Earliest date an application may be submitted to Grants.gov)
Expiration Date: September 8, 2010

Purpose.
This funding opportunity announcement (FOA) solicits research to expand the application of genetic epidemiologic methods to studies of substance and alcohol use disorders (SUDs/AUD, drug and alcohol abuse and dependence) by applying genetic epidemiologic approaches to advance our understanding of developmental trajectories of SUD/AUD, differentiate genetic and environmental factors in the development and maintenance of SUD/AUD, broaden and refine phenotypic definitions of SUDs/AUD, guide the translation of etiologic findings to treatment, prevention, gene-finding and molecular studies, and meet the methodologic challenges of the field.

Genomes 2008

Genomes 2008
Functional Genomics of Microorganisms

April 8-11, 2008
Institut Pasteur, Paris, France

Genomes 2008 is of the latest in a series of meetings including Genomes 2000 (Institut Pasteur, Paris), Genomes 2004 (Hinxton, Cambridge, UK), Microbial Genomes 2007 (Hinxton, Cambridge, UK), and the ASM-TIGR Microbial Genome Conferences (USA).

The emphasis of the meeting will be comparative analyses of pathogenic and environmental microbes, functional genomics, computational genomics and systems biology in the light of the new technological developments. Genomics has also dramatically changed studies concerning the interaction of microorganism s with their environment or, for pathogens, symbionts or commensals, their host. The newest results in this field will also be discussed.

International Congress of Genetics 2008

International Congress of Genetics 2008

Berlin, Germany
July 12-17, 2008

The field of genetics continues to witness impressive advances in understanding the hereditary basis of the structure, function and evolution of living systems. The next International Congress of Genetics, to be held in Berlin, Germany, July 12-17, 2008, will address the latest developments in this exciting frontier of science.

Impressive progress has already been made in the bioinformatic and mathematic integration of genomic data. Computational analyses of genomic data and the simulation of models of biological systems are yielding the new discipline of computational genetics as well as the first steps toward a synthetic biology.

We welcome you heartily to join us at the XX International Congress of Genetics, Berlin, 2008, to review with us the latest and exciting advances in modern genetics.

Methods of Statistical Analysis of DNA Sequence Data for Studies Relating Variation to Disease (R01)

Methods of Statistical Analysis of DNA Sequence Data for Studies Relating Variation to Disease (R01)

NIH
Department of Health and Human Services

Purpose:

This Funding Opportunity Announcement (FOA) will encourage the development of novel methods of statistical analysis of DNA sequence data in studies that aim to relate genetic variation to disease. Areas of interest include, but are not limited to, designing sequencing studies and statistical methods for relating the variation to phenotype; assessing the significance of the associations; incorporating population genetic factors such as population history, admixture, and natural selection; and finding sets of variants that may include functional variants.

Key Dates
Release/Posted Date: June 21, 2007
Opening Date: August 20, 2007 (Earliest date an application may be submitted to Grants.gov)

Genetics and Pathobiology of Vascular Cognitive Impairment (R01)

Genetics and Pathobiology of Vascular Cognitive Impairment (R01)

Department of Health and Human Services

Participating Organizations
National Institutes of Health (NIH), (http://www.nih.gov)

Purpose – The National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Aging (NIA), and the National Heart, Lung and Blood Institute (NHLBI) invite research grant applications aimed at understanding the genetics and pathobiology of Vascular Cognitive Impairment (VCI).

Despite the enormous prevalence of VCI, the biological basis of this disease has been much less well studied than that of AD. This lack has been due in part to the clinical heterogeneity of the disease, and also to poor understanding of its pathology at the cellular level. Recently, however, research in VCI has taken some critical first steps forward. A genetic form of vascular dementia, CADASIL, has been discovered, and the mutant gene identified as Notch 3. Previous research in animal models had shown Notch 3 to be important in early neural and vascular development. The finding that mutation of Notch 3 leads to stroke and dementia (both seen in CADASIL) suggests that the gene also plays an important role in the function or maintenance of vascular and/or neural cells in the adult. Consistent with this possibility, a transgenic mouse carrying the mutant form of Notch 3 has now been generated which shows degeneration of smooth muscle cells similar to that seen in human patients. These findings provide an important foothold for understanding the cell biology as well as the genetics of VCI. Moreover, the known interaction of Notch with the presenilin proteins suggests a juncture in the disease pathways underlying VCI and AD, which also could be further explored in mouse models.

Forging a connection between research and clinical applications.