Pharmacogenomics Knowledge Base, PharmGKB (R24)

Purpose. The purpose of this funding opportunity issued by NIGMS is to enable new and renewal applications to compete for the Pharmacogenetics and Pharmacogenomics Knowledge Base, PharmGKB (www.pharmgkb.org), which will be renamed the Pharmacogenomics Knowledge Base. PharmGKB is being developed to serve the needs of the entire research community in pharmacogenomics. Optimally, the knowledge base PharmGKB will present complete, comprehensive, and current knowledge in pharmacogenomics, backed by the critical datasets (which may be archived elsewhere) and the most compelling literature. There are informatics challenges to managing and integrating large and disparate sets of information, and a compelling resource should be easily used and extremely valuable to stakeholders trying to advance the field of pharmacogenomics and its implementation. The ultimate goal of pharmacogenomics is to guide appropriate therapeutic choices, and PharmGKB should support and extend modern research approaches to achieve this goal. Previously, PharmGKB was a component of the Pharmacogenetics Research Network; now the network is the subject of another funding opportunity announcement (Pharmacogenomics Research Network, RFA-GM-10-001, http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-10-001.html). PharmGKB is being renewed separately as a R24 in order to enable the knowledge base to be developed to clearly serve the needs of the entire research community in pharmacogenomics.

Key Dates
Release Date: March 5, 2009
Letters of Intent Receipt Date: May 2, 2009
Application Receipt Dates: June 2, 2009
Peer Review Date: November 2009
Council Review Date: January 2010
Earliest Anticipated Start Date: April 1, 2010
Additional Information To Be Available Date (Url Activation Date): March 1, 2009 www.nigms.nih.gov/initiatives/PGRN/RFAinfo
Expiration Date: June 3, 2009

Characterizing the Blood Stem Cell Niche (R01)

Purpose. This FOA issued by the National Heart, Lung, and Blood Institute, National Institutes of Health, solicits Research Project Grant (R01) applications in a specific area of stem cell research, the blood stem cell niche, an area critical to advancing stem cell biology and its applications to cellular therapeutics including hematopoietic stem cell transplantation. This FOA is being initiated to foster collaborative research projects and insightful approaches to dissect the cellular components and factors involved in the hematopoietic stem cell niche. Development of conditional genetic knock-out models to test the role of factors in specific cell lineages and imaging technology to facilitate following stem cell engraftment in the niche in vivo are integral to this initiative.

Key Dates
Release/Posted Date: October 17, 2008
Opening Date: December 15, 2008 (Earliest date an application may be submitted to Grants.gov)
Letters of Intent Receipt Date(s): December 8, 2008
NOTE: On-time submission requires that applications be successfully submitted to Grants.gov no later than 5:00 p.m. local time (of the applicant institution/organization).Application Due Date(s): January 6, 2009
Peer Review Date(s): April/May 2009
Council Review Date(s): May 2009
Earliest Anticipated Start Date(s): July 1, 2009
Additional Information To Be Available Date (Activation Date): Not Applicable
Expiration Date: January 7, 2009

Revolutionary Genome Sequencing Technologies – The $1000 Genome (R01)

Purpose: The National Human Genome Research Institute (NHGRI) solicits R01 grant applications to develop novel technologies that will enable extremely low-cost, high quality DNA sequencing. The goal of this initiative is to reduce the cost of sequencing a mammalian-sized genome to approximately $1000. Applicants may propose to develop full-scale sequencing systems or to investigate challenges underlying key system components. Exploration of methods other than those currently being pursued as potential $1,000 genome technologies are particularly encouraged. High-risk/high-payoff proposals are appropriate to achieve the goals of this FOA by approximately 2014

Also see the following related funding initiatives:

Revolutionary Genome Sequencing Technologies – The $1000 Genome (R21)

Revolutionary Genome Sequencing Technologies – The $1000 Genome (SBIR [R43/R44])

Revolutionary Genome Sequencing Technologies – The $1000 Genome (STTR [R41/R42])