Viral and Host Genetic Factors Regulating HIV-Associated CNS Disease (R01)

Executive Summary

Purpose. The National Institute of Mental Health (NIMH) and The National Institute of Neurological Disorders and Stroke (NINDS) solicit research grant applications to support studies focused on viral and host genetic factors involved in HIV-1 Associated Neurocognitive Disorders (HAND) in the setting of highly active anti-retroviral therapy (HAART). Recent clinical studies indicate that over 50% of HIV-infected patients manifest HAND despite receiving HAART. The focus of this initiative is to encourage studies to discover novel genetic paradigms that may account for the interactions between the virus, the host, and the therapeutic drugs in the central nervous system (CNS) that result in the pathogenesis, progression, and clinical manifestations of HAND. The use of state-of-the-art genetic approaches (including transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequencing, exome sequencing, & systems biology) to identify and validate (including in vitro models, animal models, & human samples) viral and host genetic factors which influence the pathophysiology of HAND are encouraged.

Key Dates
Release/Posted Date: July 29, 2010
Opening Date: December 6, 2010 (Earliest date an application may be submitted to
Letters of Intent Receipt Date(s): December 6, 2010
NOTE: On-time submission requires that applications be successfully submitted to no later than 5:00 p.m. local time (of the applicant institution/organization).
Application Due Date(s): January 6, 2011
Peer Review Date(s): March 2011
Council Review Date(s): May 2011
Earliest Anticipated Start Date(s): July 1, 2011
Additional Information to Be Available Date (Activation Date): Not Applicable
Expiration Date: January 7, 2011

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