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Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers

Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers

Genome Biology
8 July 2008

Background
In recent years, the molecular underpinnings of the long observed resemblance between neoplastic and immature tissue have begun to emerge. Genome-wide transcriptional profiling has revealed similar gene expression signatures in several tumor types and early developmental stages of their tissue of origin. However, it remains unclear whether such a relationship is a universal feature of malignancy, whether heterogeneities exist in the developmental component of different tumor types and to which degree the resemblance between cancer and development is a tissue-specific phenomenon.

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