International Congress of Genetics 2008

International Congress of Genetics 2008

Berlin, Germany
July 12-17, 2008

The field of genetics continues to witness impressive advances in understanding the hereditary basis of the structure, function and evolution of living systems. The next International Congress of Genetics, to be held in Berlin, Germany, July 12-17, 2008, will address the latest developments in this exciting frontier of science.

Impressive progress has already been made in the bioinformatic and mathematic integration of genomic data. Computational analyses of genomic data and the simulation of models of biological systems are yielding the new discipline of computational genetics as well as the first steps toward a synthetic biology.

We welcome you heartily to join us at the XX International Congress of Genetics, Berlin, 2008, to review with us the latest and exciting advances in modern genetics.

Methods of Statistical Analysis of DNA Sequence Data for Studies Relating Variation to Disease (R01)

Methods of Statistical Analysis of DNA Sequence Data for Studies Relating Variation to Disease (R01)

NIH
Department of Health and Human Services

Purpose:

This Funding Opportunity Announcement (FOA) will encourage the development of novel methods of statistical analysis of DNA sequence data in studies that aim to relate genetic variation to disease. Areas of interest include, but are not limited to, designing sequencing studies and statistical methods for relating the variation to phenotype; assessing the significance of the associations; incorporating population genetic factors such as population history, admixture, and natural selection; and finding sets of variants that may include functional variants.

Key Dates
Release/Posted Date: June 21, 2007
Opening Date: August 20, 2007 (Earliest date an application may be submitted to Grants.gov)

Genetics and Pathobiology of Vascular Cognitive Impairment (R01)

Genetics and Pathobiology of Vascular Cognitive Impairment (R01)

Department of Health and Human Services

Participating Organizations
National Institutes of Health (NIH), (http://www.nih.gov)

Purpose – The National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Aging (NIA), and the National Heart, Lung and Blood Institute (NHLBI) invite research grant applications aimed at understanding the genetics and pathobiology of Vascular Cognitive Impairment (VCI).

Despite the enormous prevalence of VCI, the biological basis of this disease has been much less well studied than that of AD. This lack has been due in part to the clinical heterogeneity of the disease, and also to poor understanding of its pathology at the cellular level. Recently, however, research in VCI has taken some critical first steps forward. A genetic form of vascular dementia, CADASIL, has been discovered, and the mutant gene identified as Notch 3. Previous research in animal models had shown Notch 3 to be important in early neural and vascular development. The finding that mutation of Notch 3 leads to stroke and dementia (both seen in CADASIL) suggests that the gene also plays an important role in the function or maintenance of vascular and/or neural cells in the adult. Consistent with this possibility, a transgenic mouse carrying the mutant form of Notch 3 has now been generated which shows degeneration of smooth muscle cells similar to that seen in human patients. These findings provide an important foothold for understanding the cell biology as well as the genetics of VCI. Moreover, the known interaction of Notch with the presenilin proteins suggests a juncture in the disease pathways underlying VCI and AD, which also could be further explored in mouse models.