Post-Genomics Blog

Forging a connection between research and clinical applications.

Program Announcement (PA) Number: PA-07-413

National Institutes of Health (NIH)

Genetic Epidemiology of Substance Use Disorders

Genetic Epidemiology of Substance Use Disorders (R01)
Genetic Epidemiology of Substance Use Disorders (R03)
Genetic Epidemiology of Substance Use Disorders(R21)

Key Dates.
Release/Posted Date: July 24, 2007
Opening Date: July 25, 2007 (Earliest date an application may be submitted to Grants.gov)
Expiration Date: September 8, 2010

Purpose.
This funding opportunity announcement (FOA) solicits research to expand the application of genetic epidemiologic methods to studies of substance and alcohol use disorders (SUDs/AUD, drug and alcohol abuse and dependence) by applying genetic epidemiologic approaches to advance our understanding of developmental trajectories of SUD/AUD, differentiate genetic and environmental factors in the development and maintenance of SUD/AUD, broaden and refine phenotypic definitions of SUDs/AUD, guide the translation of etiologic findings to treatment, prevention, gene-finding and molecular studies, and meet the methodologic challenges of the field.

Methods of Statistical Analysis of DNA Sequence Data for Studies Relating Variation to Disease (R01)

Methods of Statistical Analysis of DNA Sequence Data for Studies Relating Variation to Disease (R01)

NIH
Department of Health and Human Services

Purpose:

This Funding Opportunity Announcement (FOA) will encourage the development of novel methods of statistical analysis of DNA sequence data in studies that aim to relate genetic variation to disease. Areas of interest include, but are not limited to, designing sequencing studies and statistical methods for relating the variation to phenotype; assessing the significance of the associations; incorporating population genetic factors such as population history, admixture, and natural selection; and finding sets of variants that may include functional variants.

Key Dates
Release/Posted Date: June 21, 2007
Opening Date: August 20, 2007 (Earliest date an application may be submitted to Grants.gov)

Genetics and Pathobiology of Vascular Cognitive Impairment (R01)

Genetics and Pathobiology of Vascular Cognitive Impairment (R01)

Department of Health and Human Services

Participating Organizations
National Institutes of Health (NIH), (http://www.nih.gov)

Purpose – The National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Aging (NIA), and the National Heart, Lung and Blood Institute (NHLBI) invite research grant applications aimed at understanding the genetics and pathobiology of Vascular Cognitive Impairment (VCI).

Despite the enormous prevalence of VCI, the biological basis of this disease has been much less well studied than that of AD. This lack has been due in part to the clinical heterogeneity of the disease, and also to poor understanding of its pathology at the cellular level. Recently, however, research in VCI has taken some critical first steps forward. A genetic form of vascular dementia, CADASIL, has been discovered, and the mutant gene identified as Notch 3. Previous research in animal models had shown Notch 3 to be important in early neural and vascular development. The finding that mutation of Notch 3 leads to stroke and dementia (both seen in CADASIL) suggests that the gene also plays an important role in the function or maintenance of vascular and/or neural cells in the adult. Consistent with this possibility, a transgenic mouse carrying the mutant form of Notch 3 has now been generated which shows degeneration of smooth muscle cells similar to that seen in human patients. These findings provide an important foothold for understanding the cell biology as well as the genetics of VCI. Moreover, the known interaction of Notch with the presenilin proteins suggests a juncture in the disease pathways underlying VCI and AD, which also could be further explored in mouse models.

Implicating Noncoding RNAs in the Genetics of Mental Disorders (R01) (Collaborative R01) (R21)

Implicating Noncoding RNAs in the Genetics of Mental Disorders (R01)
Implicating Noncoding RNAs in the Genetics of Mental Disorders (Collaborative R01)
Implicating Noncoding RNAs in the Genetics of Mental Disorders (R21)

Department of Health and Human Services
National Institute of Mental Health (NIMH)

Program Announcement (PA) Number: PA-07-370; PA-07-371;PA-07-372;
Opening Date: May 7, 2007 (Earliest date an application may be submitted to Grants.gov).
Expiration Date: May 8, 2010

Purpose.
The purpose of this Funding Opportunity Announcement (FOA) is to invite applications that investigate the role of microRNAs and other noncoding RNAs in the etiology of mental disorders. The data generated by this effort will contribute to the disaggregation of the molecular machinery underlying mental disorders by integrating sequence specific modulators of post-transcriptional gene expression into a theoretical framework of disease pathophysiology, with the aim of rapid, widespread sharing of the resulting data to accelerate genetic analysis of human diseases.

NIH – Human Genes and the Environment Research Training Program

Human Genes and the Environment Research Training Program

Executive Summary

The National Institute of Environmental Health Sciences and the National Human Genome Research Institute will award Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32) to eligible institutions to support predoctoral, postdoctoral and short term research training to ensure the appropriate workforce is available to assume leadership roles to advance the research objectives of the Genes and Environment Initiative. This new Genes and the Environment Training Program seeks to build upon the established foundations in exposure biology and high throughput genomics to produce a new generation of scientists who are equally at home in genomics and environmental health sciences and can seamlessly interact with both groups of scientists.

The total amount to be awarded is $750,000.

The anticipated number of awards is three.

Key Dates:

Release Date: January 17, 2007
Letters of Intent Receipt Date(s): May 29, 2007
Application Receipt Date(s): June 29, 2007
Peer Review Date(s): October-November 2007
Council Review Date(s): January 2008
Earliest Anticipated Start Date: July 1, 2008
Expiration Date: June 30, 2007

Natural Environment Research Council

“Natural Environment Research Council (NERC)
NERC supports a number of competitive grant schemes for blue skies research:
* Small Research Grants support curiosity-motivated, strategic or applied research with funding of between £2k and £30k. There is a single annual call for Small Grants with a closing date of 1 September.
* Standard Research Grants support scientifically excellent curiosity-motivated research, strategic research projects in excess of £30k funding. Closing dates 1 July, 1 December.
NERC also invites applications to its Thematic Research Programmes, which operate through calls for proposals.�

Genome Canada

�Together with its five Genome Centres and with other partners, Genome Canada invests and manages large-scale research projects in key selected areas such as agriculture, environment, fisheries, forestry, health and new technology development. Genome Canada also supports research projects aimed at studying and analyzing the ethical, environmental, economic, legal and social issues related to genomics research (GE3LS ).
To date, Genome Canada has invested more than $560 million across Canada, which, when combined with funding from other partners, is expected to result in more than $1.2 billion in 112 innovative research projects and sophisticated science and technology platforms.�

Federal grant-making agencies

Grants.gov allows organizations to electronically find and apply for more than $400 billion in Federal grants. Grants.gov is THE single access point for over 1000 grant programs offered by all Federal grant-making agencies. The US Department of Health and Human Services is proud to be the managing partner for Grants.gov, an initiative that is having an unparalleled impact on the grant community.�

Research funding opportunities

Research funding opportunities from the National Institutes of Health’s National Center for Research Resources.

Grant Opportunities

�The W.M. Keck Foundation makes grants to research institutions and accredited institutions of higher learning primarily in the areas of Science and Engineering, Medical Research and Liberal Arts. Eligible institutions in these fields are U.S. accredited universities, colleges, medical schools and major, independent scientific and medical research institutions.�

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